Nm-23, c-erbB-2, and progesterone receptor expression in invasive breast cancer: correlation with clinicopathologic parameters.

摘要: Downregulation of nm-23 antimetastasis gene has been associated with disease progression in some human tumors. NPD kinase A is the product H1 isotype nm23 and its value as a marker metastatic potential well worth investigating. The expression nm23-H1 peptide was immunohistochemically evaluated 191 primary mammary cancer tissues. three-step immunoperoxidase staining procedure performed any association our results several classical clinicopathologic indicators, including hormonal status c-erbB-2 oncoprotein membrane immunoexpression, examined. NDP A-positive cytoplasmic immunolabeling noticed 64% all specimens (123/191) which frequently demonstrated positive progesterone receptor (PgR) (p = 0.001) were furthermore characterized by high PgR immunoreactivity rates. This significant both univariate multivariate statistical analysis. double (+)/PgR(+) phenotype more detected than other combined these markers. generally remarkable proportion malignant cells, either invasive or intraductal tumor components. Notably, large-cell ductal carcinomas situ lower rates when compared types. Quantitatively increased immunopositive observed special histologic types infiltrating cancers, nuclear grade tumors, levels 0.05). (-)/c-erbB-2(+) often cancers this study nm23-H1(+)/c-erbB-2(+) one. former correlated to postmenopausal ages extensive axillary nodal involvement It noteworthy that nm23-H1(-) status, on own, not statistically presence number involved lymph nodes. On contrary, immunopositivity was, paradoxically, tumors relatively TN stage. Tumor thus likely depend gene's overexpression. Possibly, favorable outcome nm23-H1(+) cases might be due fact they also express PgR, functionally differentiated phenotype.