Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression
作者： Olivier Boss , Sonia Samec , Ariane Paoloni-Giacobino , Colette Rossier , Abdul Dulloo
DOI: 10.1016/S0014-5793(97)00384-0
关键词:
摘要: Brown adipose tissue (BAT) and skeletal muscle are important sites of nonshivering thermogenesis. The uncoupling protein-1 (UCP1) is the main effector thermogenesis in BAT recently described ubiquitous UCP2 [1]has been implicated energy balance. In an attempt to better understand biochemical events underlying muscle, we screened a human cDNA library isolated three clones: UCP2, UCP3L UCP3S. novel UCP3 was 57% 73% identical UCP1 respectively, highly muscle-specific its expression unaffected by cold acclimation. This new member UCP family candidate protein for modulation respiratory control muscle.
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