Etoposide stimulates 1,25-dihydroxyvitamin D3 differentiation activity, hormone binding and hormone receptor expression in HL-60 human promyelocytic cells.
作者： Raul Torres , Consuelo Calle , Patricio Aller , Felicísima Mata
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摘要: The simultaneous administration of the DNA topoisomerase II inhibitor etoposide (0.15 mM) and 1,25-dihydroxyvitamin D3 (VD3) (10 nM) synergistically induced differentiation HL-60 human promyelocytic leukemia cells. Similar results were obtained using U-937 promonocytic cells, or inhibitors doxorubicin (15 mitoxantrone (2.5 nM). When sequential treatments used, pre-incubation with VD3 had little effect on subsequent action etoposide, while greatly potentiated VD3. In addition, treatment stimulated binding activity increased receptor mRNA protein levels. increase in hormone expression may explain, at least part, capacity to potentiate inducing
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