In vitro efficacy of liposomal amphotericin B, micafungin and fluconazole against non-albicans Candida species biofilms
作者： Akira Kawai , Yuka Yamagishi , Hiroshige Mikamo
DOI: 10.1016/J.JIAC.2015.05.007
关键词:
摘要: Non-albicans Candida species are being isolated with increasing frequency. In this study, biofilm formation by tropicalis, parapsilosis and glabrata was evaluated the activities of liposomal amphotericin B (LAB), micafungin (MFG) fluconazole (FLC) against these biofilms were assessed using a clinically relevant in vitro model system. LAB exhibited strong three non-albicans showed dose-dependent efficacy. MFG displayed paradoxical growth effect C. tropicalis biofilm. FLC ineffective for biofilms. This study shows that have unique susceptibility to LAB. The effects indicate drug may be useful treatment cases which catheter cannot removed clinical reasons.
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