Plasma acid phosphatase levels in endotoxaemia: modification by drugs and chemically detoxified endotoxins

摘要: The ability of chemically detoxified E. coli endotoxins and membrane-active agents to modify the toxicity native endotoxin in vivo was examined. time- dose-dependent increase plasma acid phosphatase activity following toxin administration rats provided a convenient quantitative measure under various experimental conditions. Treatment with either sodium hydroxide or periodate produced substances which, when injected alone, failed cause an activity. When given before endotoxin, periodate-detoxified reduction elevation enzyme caused by unmodified toxin. Pretreatment pranolium, hydrocortisone (+)-propranolol also reduced endotoxin. Mortality studies mice further independent support for effectiveness drugs as antagonists. Evidence has been found that certain conditions gentamicin may act synergistically bacterial vivo.