Variations in demography and prognosis by colon cancer location.

摘要: Aim: Tumours of the right and left colon are suggested to be different entities with prognosis. The aim was explore differences related location a colonic tumour. Patients Methods: A single-centre retrospective analysis all patients treated for cancer during 1999-2008 (n=1558) carried out. Assessed data included demography, pathology survival by location, also sub-divided into sigmoid colon. Results: Right carcinoma associated female gender, higher age poor grade differentiation; had characteristics worse stages requiring emergency surgery. Sigmoid tumours were better stage. Survival staging, which varied location. conferred overall (OS) (p<0.037) but not cancer-specific (CSS) or disease-free compared entire colon, whilst OS CSS (p<0.001) when sub-divided. Conclusion: There in demography cancer. carries best proximal definition is transition from small bowel at ileoceacal valve distally continuing rectum. rectum is, Sweden, defined as distal 15 cm measured anal verge (1). embryologic origin both midgut hindgut where latter develops part common site development malignancies, incidence slowly increasing (2, 3). Colorectal has been multi-pathway disease based on biomolecular properties (4, 5). Some these more frequent certain locations, such high microsatellite instability (MSI) Thus, there could carcinogenesis between parts bowel. have prognoses (6). Large studies shown (7). then mostly analysed two distinct parts. However, within thus sigmoidal transverse descending This concur surgical management, three main procedures right/left colectomy resection. hypothesis that fact least entities, right, sigmoidal, this study further prognosis