Invasive potential of gut mucosa-derived Fusobacterium nucleatum positively correlates with IBD status of the host.

摘要: Background: Fusobacterium nucleatum is a heterogeneous oral pathogen that also common resident of the human gut mucosa. Given some strains F. are known to be invasive and proinflammatory in mucosa, we compared isolated from patients with inflammatory bowel disease (IBD) healthy controls determine 1) whether this species was more commonly associated IBD patients; 2) gut-derived showed an increased capacity for invasion. Methods: Biopsy material obtained 56 adult undergoing colonoscopy colon cancer screening purposes or assessment irritable syndrome status (34 patients), assess presence gastrointestinal (i.e., indeterminate colitis, 22 patients). We enumerated spp. biopsy blinded fashion, then virulence potential subset using invasion assay Caco-2 model system. Results: were 63.6% 26.5% (P ¼ 0.01). In total, 69% all recovered identified as nucleatum. originating inflamed tissue significantly cell than either control < 0.05 0.001). Conclusions: This study indicates colonization intestinal mucosa by highly may useful biomarker disease. (Inflamm Bowel Dis 2011;17:1971–1978)