A HER2-binding Affibody molecule labelled with 68Ga for PET imaging: direct in vivo comparison with the 111In-labelled analogue.
作者： Vladimir Tolmachev , Irina Velikyan , Mattias Sandström , Anna Orlova
DOI: 10.1007/S00259-009-1367-7
关键词:
摘要: Purpose Overexpression of HER2 receptors is a prognostic and predictive biomarker in breast cancer number other malignancies. Radionuclide molecular imaging overexpression may influence patient management making treatment more personalized. Earlier, 111In-DOTA-ZHER2:342-pep2 (ABY-002) Affibody molecule demonstrated excellent HER2-expressing xenografts mice shortly after injection. The use the positron-emitting nuclide 68Ga instead 111In might increase both sensitivity accuracy expression quantification. goal this study was to prepare characterize 68Ga-labelled ABY-002.
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