Mismatch repair gene polymorphisms and survival in invasive ovarian cancer patients.

摘要: Abstract Aims Inherited genetic factors may help partially explain variability of survival length amongst ovarian cancer patients. Of particular interest are genes involved in DNA repair, specifically those mismatch repair (MMR). The aim this study was to investigate the possible association between common variants MMR and invasive overall survival. Method/results We examined associations 44 that tag known (minor allele frequency ⩾0.05) seven ( MLH1 , MLH3 MSH2 MSH3 MSH6 PMS1 PMS2 ) patients three case–control studies from United Kingdom (UK), Denmark California States America (USA). up 1495 women were genotyped. genotypes each polymorphism tested for with using Cox regression analysis stratified by study. A nominally significant P  = 0.04) genotype observed rs2228006 . per-rare hazard ratio (HR 95%CI) 0.84 (0.71–0.99), however, it not after adjusting multiple covariants  = 0.47). When analyses restricted serous type cancer, two SNPs showed marginal associations; HR 1.3 (1.05–1.6)  = 0.02) rs1799977 1.4 (1.03–1.9) rs6151662 MSH3. Neither covariants. Conclusion It is unlikely pathways have moderate effects on diagnosis cancer. Much larger would be needed exclude small effects.