Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features
作者： H YAMAMOTO , J PEREZPITEIRA , T YOSHIDA , M TERADA , F ITOH
DOI: 10.1016/S0016-5085(99)70499-3
关键词:
摘要: Abstract Background & Aims: Colon cancer of the microsatellite mutator phenotype (MMP) exhibits significant genotype differences from without MMP. Twenty-nine MMP-positive gastric cancers were analyzed to clarify if these also associated with distinctive clinicopathologic features. Methods: Alterations p53 , β 2 -microglobulin ( β2M ), hMLH1 and hMSH2 genes by using polymerase chain reaction, single-strand conformational polymorphism, sequencing, microallelotyping, hypermethylation assays, immunostaining. The results contrasted mutations in BAX, hMSH3 hMSH6 target for Results: Tumors MMP had a significantly lower incidence gene than other tumors often contained somatic mutations. Many concomitant genetic epigenetic alterations DNA mismatch repair genes, hMLH1, hMSH2, hMSH6. Gastric was well/moderate differentiation, distal location, better survival. Conclusions: Analysis sequences is useful classification groups different prognosis. further support concept that (gastric) represents oncogenic pathway because mutated are usually those found GASTROENTEROLOGY 1999;116:1348-1357
gastrojournal.org
elsevier.com
sci-hub.se 参考文章(52)
R Hamelin, F Muzeau, P H Cottu, J F Fléjou, G Thomas, A Estreicher, R Iggo, Inverse correlation between RER+ status and p53 mutation in colorectal cancer cell lines. Oncogene. ,vol. 13, pp. 2727- 2730 ,(1996)
F. Rosa, H. Berissi, J. Weissenbach, L. Maroteaux, M. Fellous, M. Revel, The beta2-microglobulin mRNA in human Daudi cells has a mutated initiation codon but is still inducible by interferon. The EMBO Journal. ,vol. 2, pp. 239- 243 ,(1983) , 10.1002/J.1460-2075.1983.TB01412.X
E. Stanbridge, Y. Ionov, M. Perucho, S. Casares, Hai-Yan Ge, The microsatellite mutator phenotype of colon cancer cells is often recessive. Oncogene. ,vol. 11, pp. 2303- 2310 ,(1995)
Henry T. Lynch, Thomas C. Smyrk, Patrice Watson, Stephen J. Lanspa, Jane F. Lynch, Patrick M. Lynch, R.Jennifer Cavalieri, C.Richard Boland, Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review Gastroenterology. ,vol. 104, pp. 1535- 1549 ,(1993) , 10.1016/0016-5085(93)90368-M
Hoguen Kim, Jin Jen, Bert Vogelstein, Stanley R Hamilton, None, Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences American Journal of Pathology. ,vol. 145, pp. 148- 156 ,(1994)
M. A. Rodriguez-Bigas, G. N. Ranzani, R. Fodde, A. J. Meltzer, D. Sidransky, R. W. Burr, S. N. Thibodeau, C. R. Boland, M. Perucho, S. Srivastava, S. R. Hamilton, Correspondence re: C. R. Boland et al., A National Cancer Institute Workshop on Microsatellite Instability for Cancer Detection and Familial Predisposition: Development of International Criteria for the Determination of Microsatellite Instability in Colorectal Cancer. Cancer Res., 58: 5248- 5257, 1998 (multiple letters) Cancer Research. ,vol. 59, pp. 249- 256 ,(1999)
Joo-Young Lee, Eun-Joo Seo, Mun-Gan Rhyu, Sang-Wook Choi, Ji-Min Song, Yeun-Jun Chung, Yong-Tae Jung, Microsatellite Instability-associated Mutations Associate Preferentially with the Intestinal Type of Primary Gastric Carcinomas in a High-Risk Population Cancer Research. ,vol. 56, pp. 4662- 4665 ,(1996)
Atsuo Tsuchiya, Yasuhito Yuasa, Hiromi Nagasaki, Yoshimitsu Akiyama, Rikiya Abe, Hisayoshi Sato, Toshio Yamada, Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred Cancer Research. ,vol. 57, pp. 3920- 3923 ,(1997)
Juul Wijnen, Heleen van der Klift, Hans Vasen, P Meera Khan, Fred Menko, Carli Tops, Hanne Meijers Heijboer, Dick Lindhout, Pål Møller, None, MSH2 genomic deletions are a frequent cause of HNPCC. Nature Genetics. ,vol. 20, pp. 326- 328 ,(1998) , 10.1038/3795
M S Greenblatt, W P Bennett, M Hollstein, C C Harris, Mutations in the p53 Tumor Suppressor Gene: Clues to Cancer Etiology and Molecular Pathogenesis Cancer Research. ,vol. 54, pp. 4855- 4878 ,(1994)