High microsatellite instability predicts good prognosis in intestinal-type gastric cancers.

摘要: Background and Aim:  A subset of gastric cancers showed high microsatellite instability (MSI-H). The reported clinicopathological features MSI-H are heterogeneous, specific factors associated with prognosis have not been identified. Methods:  We analyzed the characteristics prognostic in a large series (161 cases) cancers, compared results to 315 cases microsatellite-stable or low microsatellite-instable cancers. Results:  frequency was 9% (161/1786). distinct features, including female sex, older age, antral location, well-to-moderate differentiation, intestinal-type Lauren classification, expanding-type Ming non-signet-ring cell component, presence mucinous moderate-to-severe lymphoid stromal reaction, lower tumor stage. phenotype better (P = 0.044), male sex (P = 0.035, hazard ratios [HR]: 0.23), intestinal-/mixed-type classification (P < 0.001, HR: 0.09) stages (1 2, P = 0.001, 0.08) were independently-favorable factors. Conclusions:  With unique good can be classified as different cancers.