Lymphocyte-Rich Gastric Cancer: Associations with Epstein-Barr Virus, Microsatellite Instability, Histology, and Survival

摘要: Lymphocyte-rich gastric carcinomas may have a better prognosis than cancers without pronounced host inflammatory response. Two subsets of cancer-Epstein-Barr virus-positive and microsatellite instability high-have been associated with lymphocyte-rich phenotype. We assessed relationships between tumor-infiltrating lymphocytes, Epstein-Barr virus status, cancer-specific survival in 110 resected cancers. Seven patients had cancer, including 4 (3.7%) 107 consecutive patients. Tumors from 17 (16%) were designated high on the basis negative immunohistochemical staining for MLH1; all tumors intact expression MSH2 MSH6. increased lymphocytes compared virus-negative (median 450/10 HPF versus 21/10 HPF, P <.001). Microsatellite instability-high also non-microsatellite 150/10 20/HPF, affected older more likely to be intestinal Lauren classification expanding Ming classification. By univariate analysis, decreased risk death cancer was significantly low tumor stage, growth pattern, increasing lymphocyte count, status. High count status retained statistical significance as favorable prognostic factors after adjustment stage multivariate analysis. Tumor-infiltrating factor status; but did not remain significant independent prognosticator count. The association counts account improved survival.