The Clinicopathological Features of Gastric Carcinomas with Microsatellite Instability May Be Mediated by Mutations of Different “Target Genes”
作者： Carla Oliveira , Raquel Seruca , Mário Seixas , Manuel Sobrinho-Simões
DOI: 10.1016/S0002-9440(10)65665-9
关键词:
摘要: Gastric carcinomas with DNA replication errors (RER phenotype) display a particular clinicopathologic profile and carry putative favorable prognosis. The RER phenotype has been identified as microsatellite instability in noncoding regions, well repeat sequences within exons of several “target genes”: TGFβ RII, IGFII R, BAX. In an attempt to find out whether the status is significant prognostic factor gastric carcinoma multivariate analysis clinicopathological features RER+ tumors are associated mutations genes,” we evaluated series 152 cases sporadic carcinoma. Five or six loci and/or BAT 26, poly(A) tract, were analyzed each case using polymerase chain reaction electrophoresis. Thirty-five (23.0%) RER+. was closely low pTNM stage carried significantly better target genes screened for 28 13 RER− tumors. Mutations RII occurred 67.9% glandular histotype. R BAX occurred, respectively, 25.0% 32.1% cases; there trend toward association between these decreased nodal metastization wall invasiveness, respectively. We conclude that indicator such influence may be mediated by genes.
elsevier.com
sci-hub.se 参考文章(44)
R Müllenbach, P J Lagoda, C Welter, An efficient salt-chloroform extraction of DNA from blood and tissues. Trends in Genetics. ,vol. 5, pp. 391- ,(1989)
Yung Jue Bang, Jay Chang, Won Seog Kim, David Kim, David Kim, Keunchil Park, Seong Jin Kim, Expression of Transforming Growth Factor β Type II Receptor Reduces Tumorigenicity in Human Gastric Cancer Cells Cancer Research. ,vol. 57, pp. 2856- 2859 ,(1997)
Hoguen Kim, Jin Jen, Bert Vogelstein, Stanley R Hamilton, None, Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences American Journal of Pathology. ,vol. 145, pp. 148- 156 ,(1994)
Kenneth W. Kinzler, Lois L. Myeroff, James K. V. Willson, Sanford D. Markowitz, Ramon Parsons, Bo Liu, Bert Vogelstein, Microsatellite instability and mutations of the transforming growth factor β type II receptor gene in colorectal cancer Cancer Research. ,vol. 55, pp. 5548- 5550 ,(1995)
Joo-Young Lee, Eun-Joo Seo, Mun-Gan Rhyu, Sang-Wook Choi, Ji-Min Song, Yeun-Jun Chung, Yong-Tae Jung, Microsatellite Instability-associated Mutations Associate Preferentially with the Intestinal Type of Primary Gastric Carcinomas in a High-Risk Population Cancer Research. ,vol. 56, pp. 4662- 4665 ,(1996)
G. Bauer, C. P. Schmitt, J. M. Jürgensmeier, E. Viesel, P. Höfler, Transforming Growth Factor β-treated Normal Fibroblasts Eliminate Transformed Fibroblasts by Induction of Apoptosis Cancer Research. ,vol. 54, pp. 393- 398 ,(1994)
Chia-Tung Shun, Jin-Chuan Sheu, Hsiu-Po Wang, Ming-Shiang Wu, Wei-Jei Lee, Chung-Wei Lee, Jaw-Town Lin, Clinicopathological Significance of Altered Loci of Replication Error and Microsatellite Instability-associated Mutations in Gastric Cancer Cancer Research. ,vol. 58, pp. 1494- 1497 ,(1998)
Yasuhito Yuasa, Yoshimitsu Akiyama, Shi-Long Lu, Wen-Cong Zhang, Tadashi Nomizu, Genomic structure of the transforming growth factor β type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers Cancer Research. ,vol. 56, pp. 4595- 4598 ,(1996)
Pelayo Correa, Yih-horng Shiao, Phenotypic and Genotypic Events in Gastric Carcinogenesis Cancer Research. ,vol. 54, ,(1994)
C.P. Minniti, E.C. Kohn, J.H. Grubb, W.S. Sly, Y Oh, H.L. Müller, R.G. Rosenfeld, L.J. Helman, The insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor mediates IGF-II-induced motility in human rhabdomyosarcoma cells Journal of Biological Chemistry. ,vol. 267, pp. 9000- 9004 ,(1992) , 10.1016/S0021-9258(19)50379-9