Histocompatibility (HL-A) Antigens Associated with Systemic Lupus Erythematosus

摘要: Abstract Systemic lupus erythematosus is a disease characterized by several immunologic abnormalities. We determined the HL-A antigens of 40 patients standard lymphocyte cytotoxicity test. Specificity HL-A8 was present in 33 per cent, and W15 (LND) cent patients, as compared to control population frequencies 16 (p less than 0.025) 10 0.0005), respectively. Nineteen other did not differ significantly between population, no unusually frequent phenotypes were observed. The association histocompatibility loci susceptibility certain diseases may be mediated histocompatibility-linked immune response genes analogous such associations demonstrated mice. Other possible mechanisms for this are that represent specific receptor sites attachment virus "cross-tolerance" enables viral mimic antigens.