Recent developments in the determination of residual solvents in pharmaceutical products by microextraction methods

摘要: Residual solvents, or organic volatile impurities, are a potential toxic risk for drugs and pharmaceutical products have been concern of manufacturers many years. This review is to describe discuss applications microextraction techniques the extraction such volatiles product analysis. For better clarification, micro-extraction applied this purpose divided into two categories solid phase solvent-based (i.e. single drop dispersive liquid–liquid) micro-extraction. As can be seen below, attempts employ these determination residual solvents in mainly reported recent years, after their development, therefore not too references found included first article. To enable routine application different modes microextractions real-world problems, more operational convenience some form automation would needed, especially microextractions.