Cyclophilin A Promotes Cardiac Hypertrophy in Apolipoprotein E–Deficient Mice

摘要: Objective— Cyclophilin A (CyPA, encoded by Ppia ) is a proinflammatory protein secreted in response to oxidative stress mice and humans. We recently demonstrated that CyPA increased angiotensin II (Ang II)–induced reactive oxygen species (ROS) production the aortas of apolipoprotein E ( Apoe −/− mice. In this study, we sought evaluate role Ang II–induced cardiac hypertrophy. Methods Results— Cardiac hypertrophy was not significantly different between +/+ infused with (1000 ng/min per kg for 4 weeks). Therefore, investigated effect under conditions high ROS inflammation using contrast mice, exhibited less Bone marrow cell transplantation showed cells intrinsic heart plays an important hypertrophic response. production, fibroblast proliferation, migration were markedly decreased fibroblasts. Furthermore, directly induced cultured neonatal myocytes. Conclusion— required II–mediated potentiating stimulating proliferation fibroblasts, promoting myocyte