Genetic Variations of Melatonin Receptor Type 1A are Associated with the Clinicopathologic Development of Urothelial Cell Carcinoma.
作者： Yung-Wei Lin , Shian-Shiang Wang , Yu-Ching Wen , Min-Che Tung , Liang-Ming Lee
DOI: 10.7150/IJMS.20629
关键词:
摘要: Melatonin counteracts tumor occurrence and cell progression in several cancer types vitro vivo. It acts predominantly through its melatonin receptor type 1A (MTNR1A), genetic variations of MTNR1A affect the susceptibility diseases cancer. The purpose this study was to explore effect gene polymorphisms on clinicopathological characteristics urothelial carcinoma (UCC). We recruited 272 patients with UCC normal controls analyze three common single-nucleotide (SNPs) (rs2119882, rs13140012, rs6553010) related risk relevance according a TaqMan-based real-time polymerase chain reaction (PCR). found that these SNPs were not associated susceptibility. However, who had at least one G allele rs6553010 (in intron 1) higher (1.768-fold, 95% confidence interval: 1.068~1.849) developing an invasive stage (p < 0.026), compared those AA homozygotes. In conclusion, polymorphic genotypes might contribute ability predict aggressive phenotypes UCC. This is first provide insights into factors intronic variants clinicopathologic development Taiwan.
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