1-δ9-Tetrahydrocannabinol: Neurochemical and Behavioral Effects in the Mouse
作者： D. Holtzman , R. A. Lovelil , J. H. Jaffe , D. X. Freedman
DOI: 10.1126/SCIENCE.163.3874.1464
关键词:
摘要: Administration of pure 1-delta(9)-tetrahydrocannabinol to mice had the following dose-dependent nzeurochemical and behavioral effects: a slight but significant increase in concentrations 5-hydroxytryptamine whole brain; decrease concentration norepinephrine brain after administration low doses an high doses; diminished spontaneous activity, mloderate hypothermnia, hypersetisitivity tactile auditory stimiuli, ataxia sedation, pronounced hypothermia, markedly spon taneous activity reactivity doses. The duration effects on body temperature correlated generally with changes amines. characteristic amines do not correspond exactly those observed other psychotropic drugs.
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harvard.edu参考文章(13)
Charles B. Smith, EFFECTS OF d-AMPHETAMINE UPON BRAIN AMINE CONTENT AND LOCOMOTOR ACTIVITY OF MICE Journal of Pharmacology and Experimental Therapeutics. ,vol. 147, pp. 96- 102 ,(1965)
Friedhelm Korte, Helmut Sieper, Zur chemischen klassifizierung von pflanzen Journal of Chromatography A. ,vol. 13, pp. 90- 98 ,(1964) , 10.1016/S0021-9673(01)95077-0
E. S. Boyd, R. Dagirmanjian, SOME PHARMACOLOGICAL EFFECTS OF TWO TETRAHYDROCANNABINOLS Journal of Pharmacology and Experimental Therapeutics. ,vol. 135, pp. 25- 33 ,(1962)
G. K. Aghajanian, W. E. Foote, M. H. Sheard, Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe Science. ,vol. 161, pp. 706- 708 ,(1968) , 10.1126/SCIENCE.161.3842.706
Daniel X. Freedman, On the Use and Abuse of LSD Archives of General Psychiatry. ,vol. 18, pp. 330- 347 ,(1968) , 10.1001/ARCHPSYC.1968.01740030074008
J.A.R. Mead, K.F. Finger, A single extraction method for the determination of both norepinephrine and serotonin in brain Biochemical Pharmacology. ,vol. 6, pp. 52- 53 ,(1961) , 10.1016/0006-2952(61)90069-7
John A. Rosecrans, Richard A. Lovell, Daniel X. Freedman, Effects of lysergic acid diethylamide on the metabolism of brain 5-hydroxytryptamine☆ Biochemical Pharmacology. ,vol. 16, pp. 2011- 2021 ,(1967) , 10.1016/0006-2952(67)90313-9
C. L. Scheckel, E. Boff, P. Dahlen, T. Smart, Behavioral Effects in Monkeys of Racemates of Two Biologically Active Marijuana Constituents Science. ,vol. 160, pp. 1467- 1469 ,(1968) , 10.1126/SCIENCE.160.3835.1467
Harris Isbell, C. W. Gorodetzsky, D. Jasinski, U. Claussen, F. v. Spulak, F. Korte, Effects of (--)delta-9-trans-tetrahydrocannabinol in man. Psychopharmacology. ,vol. 11, pp. 184- 188 ,(1967) , 10.1007/BF00401256
Jack D. Barchas, Daniel X. Freedman, BRAIN AMINES: RESPONSE TO PHYSIOLOGICAL STRESS. Biochemical Pharmacology. ,vol. 12, pp. 1232- 1235 ,(1963) , 10.1016/0006-2952(63)90101-1