Oral agents in the management of type 2 diabetes mellitus.

摘要: Despite exhaustive efforts to better manage patients with type 2 diabetes mellitus (formerly known as non-insulin-dependent mellitus), attempts at maintaining near normal blood glucose levels in these remains unsatisfactory. This continues pose a real challenge physicians the prevalence of this disease United States rise. Type is defined syndrome characterized by insulin deficiency, resistance and increased hepatic output. Medications used treat are designed correct one or more metabolic abnormalities. Currently, there five distinct classes hypoglycemic agents available, each class displaying unique pharmacologic properties. These sulfonylureas, meglitinides, biguanides, thiazolidinediones alpha-glucosidase inhibitors. In for whom diet exercise do not provide adequate control, therapy single oral agent can be tried. When choosing an agent, it prudent consider both patient- drug-specific characteristics. If control attained using combination different mechanisms action may have additive therapeutic effects result glycemic control.