Risk factors for osteoporosis and fragility fractures in patients with systemic lupus erythematosus

摘要: Osteoporosis (OP) and fragility fractures (FFx) are a known comorbidity in patients with systemic lupus erythematosus (SLE). This work aimed at evaluating (1) the prevalence of OP FFx cohort SLE (2) risk factors associated both FFx. The following data were collected from clinical charts: age, sex, menopausal status (MP), body mass index, smoking habits, disease duration, daily dose cumulative glucocorticoids (GCs), type organ involvement, comorbidities medications. Data on bone metabolism, calcium vitamin D supplementation treatment bisphosphonates, teriparatide or denosumab collected, together mineral density (BMD) values (measured by dual-energy X-ray absorptiometry (DXA)) history (occurred after onset unrelated to trauma). reduced BMD defined according WHO. 186 included (women 175, men 11; mean age 46.4±13 years, duration 14.9±9 years). At their last visit, 97 (52.2%) had 52 (27.9%) OP. 22 (11.8%), all women, least one FFx; six (27.3%) pre-menopausal. On univariate analysis, GC, MP, therapy antiepileptics chronic renal failure (CRF) correlated (p<0.03); total amount CRF, anticoagulants (AC) antiepileptic (p<0.05). multivariate logistic model confirmed direct association MP (p≤0.01) AC (p<0.03). In conclusion, low is frequently observed SLE, also premenopausal patients. Together traditional (age, GC), CRF treatments seem be higher profile for occurrence.