Parental military service, agent orange exposure, and the risk of rhabdomyosarcoma in offspring.

摘要: Objective To evaluate the role of parental military service-related exposures and rhabdomyosarcoma (RMS) risk in offspring using data from a large case-control study childhood RMS. Study design Cases (n = 319) were enrolled third trial run by Intergroup Rhabdomyosarcoma Group. Population-based controls pair-matched to cases on race, sex, age. Conditional logistic regression was used their associations with RMS generating aORs 95% CIs. Statistical significance defined as P Results There no significant between service The strongest association maternal service; however, this attenuated did not remain after adjusting for covariates (aOR = 2.75, CI 0.71, 10.62). An elevated effect estimate found when assessing paternal exposure Agent Orange (AO) but statistically (aOR = 1.72, 0.55, 5.41). Conclusions We little evidence that AO influences offspring. These findings are notable light continuing controversies surrounding intergenerational effects exposure.