Chemokines, mononuclear cells and the nervous system: heaven (or hell) is in the details.
作者： Natalia M Rebenko-Moll , LiPing Liu , Astrid Cardona , Richard M Ransohoff
DOI: 10.1016/J.COI.2006.09.005
关键词:
摘要: Chemokines and their receptors are essential elements in leukocyte trafficking during health disease. There three (or more) distinct routes of entry into the central nervous system (CNS), molecular mechanisms physiological neuroinflammatory recruitment to CNS slowly coming view. Migration immune cells cerebrospinal fluid supports immunosurveillance. Current knowledge determinants that direct pathology relies large part on studies multiple sclerosis its models including experimental autoimmune encephalomyelitis. Overlapping signals responsible for migration specific pathological inflammation host defense, raising challenges opportunities therapeutic manipulation.
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