Oncostatin M Secreted by Skin Infiltrating T Lymphocytes Is a Potent Keratinocyte Activator Involved in Skin Inflammation

摘要: Cutaneous inflammatory diseases such as psoriasis vulgaris and atopic dermatitis are associated with altered keratinocyte function, well a particular cytokine production profile of skin-infiltrating T lymphocytes. In this study we show that normal human epidermal keratinocytes express functional type II oncostatin-M (OSM) receptor (OSMR) consisting the gp130 OSMRbeta components, but not I OSMR. The OSMR is expressed in skin lesions from both psoriatic patients those dermatitis. Its ligand, OSM, induces via recruitment STAT3 MAP kinase pathways gene expression primary reconstituted epidermis characteristic proinflammatory innate immune responses. Moreover, OSM potent stimulator migration vitro increases thickness epidermis. transcripts enhanced dermatitic compared healthy mirror by cells isolated diseased lesions. Results microarray analysis comparing gene-modulating effects 33 different cytokines indicate activator similar to TNF-alpha, IL-1, IL-17, IL-22 it acts synergy latter induction S100A7 beta-defensin 2 expression, skin. Taken together, these results demonstrate its play an important role cutaneous responses general specific distinct depending on environment.