Creation of psoriatic plaques: the ultimate tumor suppressor pathway. A new model for an ancient T-cell-mediated skin disease. Viewpoint.
作者： Brian J. Nickoloff
DOI: 10.1034/J.1600-0560.2001.280201.X
关键词:
摘要: From an oncological and immunological perspective, the T-cell-mediated induction of psoriatic plaques should be prone to malignant transformation as phenotype includes: chronic inflammation, epidermal hyperplasia, prolonged survival elevated telomerase levels in lesional keratinocytes, well angiogenesis, exposure carcinogens immunosuppressants. However, conversion a plaque squamous cell carcinoma is exceedingly rare. This paper explores possible molecular mechanism for tumor suppressor pathway lesions, with emphasis on putative senescence-switch involving p16.
blackwell-synergy.com参考文章(74)
Gary Clayman, Mario A. Luna, Helmuth Goepfert, Syeling Lai, Adel K El-Naggar, Jiun-Kae Jack Lee, John G. Batsakis, Methylation, a major mechanism of p16/CDKN2 gene inactivation in head and neck squamous carcinoma. American Journal of Pathology. ,vol. 151, pp. 1767- 1774 ,(1997)
Brian J. Nickoloff, Rama Jasty, Valerie P. Castle, Craig B. Thompson, Raj S. Mitra, Tamara Wrone-Smith, Keratinocytes derived from psoriatic plaques are resistant to apoptosis compared with normal skin American Journal of Pathology. ,vol. 151, pp. 1321- 1329 ,(1997)
C. Missero, E. Marchetti, G. P. Dotto, S. Ramón y Cajal, Dermal fibroblasts tumor suppression of ras-transformed keratinocytes is associated with induction of squamous cell differentiation. American Journal of Pathology. ,vol. 145, pp. 846- 855 ,(1994)
Gerald D. Weinstein, Phillip Frost, Abnormal Cell Proliferation in Psoriasis**From the Department of Dermatology, University of Miami School of Medicine, Miami, Florida. Journal of Investigative Dermatology. ,vol. 50, pp. 254- 259 ,(1968) , 10.1038/JID.1968.37
Craig B. Thompson, Charles M. Rudin, John C. Pena, A Bcl-xl Transgene Promotes Malignant Conversion of Chemically Initiated Skin Papillomas Cancer Research. ,vol. 58, pp. 2111- 2116 ,(1998)
Henry Hennings, James E. Strickland, Stuart H. Yuspa, Masato Ueda, A model for initiated mouse skin: suppression of papilloma but not carcinoma formation by normal epidermal cells in grafts on athymic nude mice. Cancer Research. ,vol. 52, pp. 1439- 1444 ,(1992)
Judith Campisi, The Role of Cellular Senescence in Skin Aging Journal of Investigative Dermatology. ,vol. 3, pp. 1- 5 ,(1998) , 10.1038/JIDSYMP.1998.2
Sheelagh Frame, Allan Balmain, Integration of positive and negative growth signals during ras pathway activation in vivo. Current Opinion in Genetics & Development. ,vol. 10, pp. 106- 113 ,(2000) , 10.1016/S0959-437X(99)00052-0
Robert A Weinberg, The Cat and Mouse Games That Genes, Viruses, and Cells Play Cell. ,vol. 88, pp. 573- 575 ,(1997) , 10.1016/S0092-8674(00)81897-8
C. Missero, S. Ramon y Cajal, G. P. Dotto, Escape from transforming growth factor beta control and oncogene cooperation in skin tumor development. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 9613- 9617 ,(1991) , 10.1073/PNAS.88.21.9613