Pharmacokinetics of single-dose daptomycin in patients with suspected or confirmed neurological infections.

摘要: There are currently few or no published data on the amount of cerebrospinal fluid (CSF) penetration daptomycin in patients with suspected documented neurosurgical infections. We conducted a prospective study, assessing pharmacokinetics and CSF single intravenous dose administered at 10 mg/kg, based total body weight (TBW), six indwelling external shunts meningitis ventriculitis. Each patient had four blood samples drawn simultaneously specific times after end infusion: 30 min, 6 h, 12 24 h. Pharmacokinetic parameters serum were calculated using standard noncompartmental methods, was assayed high-performance liquid chromatography (for serum) mass spectrometry CSF). The mean (± deviation [SD]) maximum measured concentrations 93.7 ± 17.3 mg/liter 0.5 h postinfusion 0.461 0.51 postinfusion. SD) minimum 13.8 4.8 0.126 0.12 penetration, determined by area under concentration-time curve (AUC(CSF))/(AUC(serum) ratio), 0.8%. Corrected for protein binding, overall 11.5%. Additional pharmacokinetic studies evaluating multiple and/or higher dosages necessary human subjects to better characterize patients.