Fishing Pluripotency Mechanisms In Vivo

摘要: To understand the molecular mechanisms that regulate biology of embryonic stem cells (ESCs) it is necessary to study how they behave in vivo their natural environment. It particularly important roles and interactions different proteins involved pluripotency use this knowledge for therapeutic purposes. The recent description key factors like Oct4 Nanog non-mammalian species has introduced other animal models, such as chicken, Xenopus, zebrafish medaka, vivo. These models complement mouse model have provided new insights into evolution functions during development. Furthermore, previously identified teleost fish Klf4, STAT3, Sox2, telomerase Tcf3 can now be studied context a functional network. many experimental advantages will fuel rapid analysis development identification molecules governing pluripotency.