作者: Steven R. Deitcher , Teresa L. Carman , Kandice Kottke-Marchant
DOI: 10.1177/107602960200800410
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摘要: Acquired hemophilia A is a life-threatening immune-mediated hemorrhagic disorder that most often found in individuals older than 50 who present with an unexplained activated partial thromboplastin time (aPTT) prolongation and clinically significant bleeding. The prolonged aPTT associated acquired reflects factor VIII activity deficiency due to neutralizing or clearing autoantibodies. Deep venous thrombosis, contrast, veno-occlusive several distinct hypercoagulable states can result morbidity mortality pulmonary embolism, thrombus extension, the post-thrombotic syndrome. setting of thrombosis may reflect presence lupus anticoagulant. In absence accurate diagnosis immediate institution specific therapy, both disorders be fatal. Three cases inhibitors included aPTT, bleeding, duplex ultrasound evidence deep are presented. diagnostic therapeutic challenges posed by these as well proposed mechanism which pathologic develop patient bleeding discussed.