Widespread brain dysconnectivity associated with psychotic-like experiences in the general population.

摘要: It is becoming increasingly clear that psychosis occurs along a continuum. At the high end are formal psychotic disorders such as schizophrenia, and at low-end individuals who experience occasional symptoms, but otherwise healthy (non-clinical psychosis, NCP). Schizophrenia has been shown to be marked by altered patterns of connectivity between brain regions, it not known if dysconnectivity exists in NCP. In current study we used functional magnetic resonance imaging (fMRI) compare resting-state NCP (n = 25) controls (n = 27) for four networks interest (fronto-parietal, cingulo-opercular, default mode, cerebellar networks). showed reduced compared regions mode network frontal all thalamus. greater within control networks. Further, positive symptom scores were positively correlated with cingulo-opercular visual cortex, negatively posterior parietal cortex dorsal premotor cortex. Connectivity was controls. Taken together, these findings demonstrate spectrum abnormal underlies continuum, sub-clinical experiences represent key population understanding pathogenic processes.