23Na and 7Li NMR Studies of Mammalian Cells: Assessment of Cation Transport and Cytoskeletal Structure with Application to Manic Depressive Disease

摘要: The regulation of Na+ trans-membrane fluxes and intracellular concentrations, is fundamental importance to human biological processes. Exchange processes serve alter the chemical state ion position carefully controlled equilibria. Alterations in transmembrane unidirectional rate constants with resultant alterations concentration have been implicated a number disease such as cystic fibrosis (Sorscher et al 1982; Katz 1978; Taylor 1979), essential hypertension (Clegg Canessa 1980; Duhm Garay Davidson Blaustein 1977), manic-depressive (Naylor 1976; Pandey 1977; Dorus cellular proliferative responses during mitogenesis oncogenesis (Cone 1971; Cameron Koch 1979; Rozenquat 1980).