Genome-wide identification of 99 autophagy-related (Atg) genes in the monogonont rotifer Brachionus spp. and transcriptional modulation in response to cadmium.

摘要: Autophagy originated from the common ancestor of all life forms, and its function is highly conserved yeast to humans. plays a key role in various fundamental biological processes including defense, has developed through serial interactions multiple gene sets referred as autophagy-related (Atg) genes. Despite their significance metazoan evolution, few studies have been conducted identify these genes aquatic invertebrates. In this study, we identified whole Atg four Brachionus rotifer spp., namely B. calyciflorus, koreanus, plicatilis, rotundiformis, searches entire genomes; annotated them according nomenclature. Twenty-four orthologous were present spp. while three additional duplicates genome indicating that had diversified during speciation. Also, transcriptional responses cadmium exposure indicated regulation by cadmium-induced oxidative-stress-related signaling pathways. This study provides valuable information on 99 involved autophagosome formation with modulation response cadmium, context autophagy damage response.