Mechanisms of Lymphocyte Activation and Immune Regulation

摘要: During the past 5 years rapid progress has been made in understanding of biochemical pathways for signal transduction lymphocyte activation. Gene cloning technology instrumental defining and making available pure form a number growth differentiation factors, characterization their receptors, delineation genes T cell receptor. This book is divided into 6 sections. Section 1 deals with molecular structure 2 discusses role receptor, membrane ion channels The structures biological immunological effects interleukin 1, 3 are presented 3. section also details receptor its use as target therapy certain leukemias. 4 includes events which occur following delivery B activation, proliferation, by antigen, growth/differentiation factors. stimulating factors discussed. oncogene expression cellular activation included 5. basis natural killing cyc1osporin A-mediated immunosuppression discussed detail 6. We hope this will serve reference work on basic mechanisms immunologists biologists.