Mice With Decreased Number of Interneurons Exhibit Aberrant Spontaneous and Oscillatory Activity in the Cortex.

摘要: GABAergic (γ-aminobutyric acid) neurons are inhibitory and protect neural tissue from excessive excitation. Cortical play a pivotal role for the generation of synchronized cortical network oscillations. Imbalance between excitatory mechanisms underlies many neuropsychiatric disorders is correlated with abnormalities in oscillatory activity, especially gamma frequency range (30-80 Hz). We investigated functional changes activity response to developmentally reduced inhibition adult mouse barrel cortex (BC). used model that displays ∼50% fewer interneurons due loss Rac1 protein Nkx2.1/Cre-expressing cells [Rac1 conditional knockout (cKO) mice], examine how this developmental may affect basal synaptic transmission, plasticity, spontaneous neuronal oscillations BC. The decrease number increased as examined by recording field postsynaptic potentials (fEPSPs) layer II networks cKO cortex, decreased long-term potentiation (LTP) tetanic stimulation but did not alter pair-pulse ratio (PPR). Furthermore, under conditions, brain slices exhibit enhanced sensitivity susceptibility emergent activity. also find results local alterations oscillations, exhibiting power low frequencies (delta, theta, alpha) Hz) an extra aberrant peak high (80-150 Therefore, our data show disruption alters properties while it additionally disrupts synchronization