Functional roles of protein nitration in acute and chronic liver diseases.

摘要: Nitric oxide, when combined with superoxide, produces peroxynitrite, which is known to be an important mediator for a number of diseases including various liver diseases. Peroxynitrite can modify tyrosine residue(s) many proteins resulting in protein nitration, may alter structure and function each target protein. Various proteomics immunological methods mass spectrometry both high pressure liquid chromatography 2D PAGE have been employed identify characterize nitrated from pathological tissue samples determine their roles. However, these contain few technical problems such as low efficiencies the detection limited labor intensiveness. Therefore, systematic approach efficiently functional roles likely shed new insights into understanding mechanisms hepatic disease pathophysiology subsequent development therapeutics. The aims this review are briefly describe In addition, we specifically study causal or consequences promoting acute chronic alcoholic nonalcoholic fatty We finally discuss translational research applications by analyzing evaluating efficacies potentially beneficial agents prevent treat other tissues.