Hypothesis: prenatal ethanol-induced birth defects and retinoic acid.
作者： Raju K. Pullarkat
DOI: 10.1111/J.1530-0277.1991.TB00561.X
关键词:
摘要: A hypothesis is presented to explain the biochemical basis of ethanol-induced birth defects. Prenatal ethanol exposure causes central nervous system and limb abnormalities in humans animals. Retinoic acid didehydroretinoic are known play an important role developments. Ethanol inhibit formation retinoic from retinol deplete hepatic retinoid levels. It hypothesized that reduces levels developing embryo either by inhibiting conversion and/or depleting level retinol, thereby causing abnormalities.
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