Comparison of the Efficacy, Safety and Tolerability of Azithromycin and Co-Amoxiclav in the Treatment of Acute Periapical Abscesses:
作者： CF Adriaenssen
DOI: 10.1177/030006059802600506
关键词:
摘要: The activity, safety and tolerability of the azalide azithromycin were compared with those co-amoxiclav in treatment acute periapical abscesses adults an open, randomized, multicentre comparative study. Patients either sex, recruited from 106 dental practices Belgium, aged between 18 75 years had not requiring drainage, confirmed by radiology. Azithromycin was administered as a 500-mg tablet orally once daily for 3 days (n = 150) 625-mg capsule three times daily, 5-10 153). Both before after treatment, masticatory pain, percussion headache, oedema redness soft tissue graded on four-point scale. Overall clinical success (cure plus improvement) seen 131/144 (91%) evaluable patients receiving 142/148 (96%) (difference significant). There no significant difference two groups incidence or severity adverse events number discontinuations because events.
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paperity.org参考文章(20)
Jorgen Slots, Lennart Bragd, Maude Wikstrom, Gunnar Dahlen, The occurrence of Actinobacillus actinomycetemcomitans, Bacteroides gingivalis and Bacteroides intermedius in destructive periodontal disease in adults Journal of Clinical Periodontology. ,vol. 13, pp. 570- 577 ,(1986) , 10.1111/J.1600-051X.1986.TB00849.X
L.E. Fisher, R.R.B. Russell, The Isolation and Characterization of Milleri Group Streptococci from Dental Periapical Abscesses Journal of Dental Research. ,vol. 72, pp. 1191- 1193 ,(1993) , 10.1177/00220345930720080501
Gary V. Vigil, Blake E. Wayman, Steve E. Dazey, Craig B. Fowler, Donald V. Bradley, Identification and antibiotic sensitivity of bacteria isolated from periapical lesions Journal of Endodontics. ,vol. 23, pp. 110- 114 ,(1997) , 10.1016/S0099-2399(97)80256-7
Göran Sundqvist, Taxonomy, Ecology, and Pathogenicity of the Root Canal Flora Oral Surgery, Oral Medicine, Oral Pathology. ,vol. 78, pp. 522- 530 ,(1994) , 10.1016/0030-4220(94)90047-7
G. Foulds, R. M. Shepard, R. B. Johnson, The pharmacokinetics of azithromycin in human serum and tissues Journal of Antimicrobial Chemotherapy. ,vol. 25, pp. 73- 82 ,(1990) , 10.1093/JAC/25.SUPPL_A.73
J.D. Williams, J.P. Maskell, H. Shain, G. Chrysos, A.M. Sefton, H.Y. Fraser, J.M. Hardie, Comparative in-vitro activity of azithromycin, macrolides (erythromycin, clarithromycin and spiramycin) and streptogramin RP 59500 against oral organisms Journal of Antimicrobial Chemotherapy. ,vol. 30, pp. 27- 37 ,(1992) , 10.1093/JAC/30.1.27
R Pajukanta, S Asikainen, M Saarela, S Alaluusua, H Jousimies-Somer, In vitro activity of azithromycin compared with that of erythromycin against Actinobacillus actinomycetemcomitans. Antimicrobial Agents and Chemotherapy. ,vol. 36, pp. 1241- 1243 ,(1992) , 10.1128/AAC.36.6.1241
Tecla Malizia, Milvana R. Tejada, Emilia Ghelardi, Sonia Senesi, Mario Gabriele, Maria R. Giuca, Corrado Blandizzi, Romano Danesi, Mario Campa, Mario Del Tacca, Periodontal tissue disposition of azithromycin. Journal of Periodontology. ,vol. 68, pp. 1206- 1209 ,(1997) , 10.1902/JOP.1997.68.12.1206
G. Sundqvist, Associations between microbial species in dental root canal infections Oral Microbiology and Immunology. ,vol. 7, pp. 257- 262 ,(1992) , 10.1111/J.1399-302X.1992.TB00584.X
J M Hardie, Oral microbiology: current concepts in the microbiology of dental caries and periodontal disease. British Dental Journal. ,vol. 172, pp. 271- 278 ,(1992) , 10.1038/SJ.BDJ.4807849