A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity

作者: Anna Astashkina , Brenda Mann , David W. Grainger

DOI: 10.1016/J.PHARMTHERA.2012.01.001

关键词:

摘要: Drug candidate and toxicity screening processes currently rely on results from early-stage in vitro cell-based assays expected to faithfully represent essential aspects of in vivo …

参考文章(250)
Joseph Mattana, Linda Margiloff, Pratima Sharma, Pravin C. Singhal, OXIDATION OF THE MESANGIAL MATRIX METALLOPROTEINASE-2 IMPAIRS GELATINOLYTIC ACTIVITY Inflammation. ,vol. 22, pp. 269- 276 ,(1998) , 10.1023/A:1022396015294
Peter O'Brien, Jeffrey R. Haskins, In vitro cytotoxicity assessment. Methods of Molecular Biology. ,vol. 356, pp. 415- 425 ,(2007) , 10.1385/1-59745-217-3:415
義人 筏, Tissue engineering : fundamentals and applications Academic Press/Elsevier. ,(2006)
T Bricio, V Alvarez, F Mampaso, A Molina, A Barat, F Sánchez-Madrid, A Martín, Prevention of mercuric chloride-induced nephritis in the brown Norway rat by treatment with antibodies against the alpha 4 integrin. Journal of Immunology. ,vol. 153, pp. 2313- 2320 ,(1994)
José M. Casasnovas, Joanna K. Bickford, Timothy A. Springer, The Domain Structure of ICAM-1 and the Kinetics of Binding to Rhinovirus Journal of Virology. ,vol. 72, pp. 6244- 6246 ,(1998) , 10.1128/JVI.72.7.6244-6246.1998
Paola Perini, Antonio Bertolotto, Daniela De Pascalis, Paolo Gallo, Antonella Facchinetti, Giovanni Biasi, Piero Bulian, Angelo R. Massaro, Interferon-beta (INF-beta) antibodies in interferon-beta1a- and interferon-beta1b-treated multiple sclerosis patients. Prevalence, kinetics, cross-reactivity, and factors enhancing interferon-beta immunogenicity in vivo. European Cytokine Network. ,vol. 12, pp. 56- 61 ,(2001)
Richard O. Hynes, Integrins: Bidirectional, Allosteric Signaling Machines Cell. ,vol. 110, pp. 673- 687 ,(2002) , 10.1016/S0092-8674(02)00971-6
Janusz Franco‐Barraza, Dorothy A. Beacham, Michael D. Amatangelo, Edna Cukierman, Preparation of Extracellular Matrices Produced by Cultured and Primary Fibroblasts Current protocols in pharmacology. ,vol. 71, ,(2006) , 10.1002/CPCB.2
Benjamin Geiger, Alexander Bershadsky, Roumen Pankov, Kenneth M. Yamada, Transmembrane crosstalk between the extracellular matrix and the cytoskeleton Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 793- 805 ,(2001) , 10.1038/35099066