Distributions of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) in Japan and their toxicities

摘要: Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are end products of many fluorochemical compounds in the natural environment. The aim this review is to summarize several studies Japan characterize toxicities these compounds. We also compared levels contamination with those reported from various countries illustrate unique situation toxicological issues within Japan. PFOA PFOS concentrations surface water ranges 0.1-67,000 ng/L 0.1-526 ng/L, respectively. While origin remains unknown, present very likely have been released a few industries. atmosphere 71.8-919 pg/m3 2.3-21.8 pg/m3, Japanese serum range an undetectable level 52.2 ng/ml 0.2 57.7 ng/ml, inhabitants Kyoto higher than other cities. One epidemiological study conducted by 3M revealed increase prostate cancer mortality [3.3-fold (95% CI, 1.02-10.6)] among workers exposed PFOA. Another bladder (SMR 12.77, 95% CI 2.63-37.35) PFOS. had low order toxicity acute rodents; however, they exhibited versatile primates. Both chemicals carcinogenic rodents, causing reproductive toxicity, neurotoxicity, hepatotoxicity. Additionally, peroxisome proliferation calcium channel modulation demonstrated effects. There large interspecies differences toxicokinetics.