Biliary excretion and cerebrospinal fluid partition of perfluorooctanoate and perfluorooctane sulfonate in humans
作者： Kouji H. Harada , Shuhei Hashida , Takaaki Kaneko , Katsunobu Takenaka , Mutsuko Minata
DOI: 10.1016/J.ETAP.2007.04.003
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摘要: Abstract Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are detected in the environment and, more specifically, wildlife humans. The large variation reported biological half-lives for PFOA PFOS has remained unexplored. In this study, we aimed to evaluate their partition from serum bile cerebrospinal fluid (CSF) Four pairs of bile, 7 CSF were donated by patients. considering biliary excretion, median concentrations samples 3.8 23.2 ng/mL, respectively, whereas those 1.0 27.9 ng/mL, respectively. ratio (bile/serum: 0.60) was significantly higher than that PFOA, 0.21 (p
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