Effect of 4 ' galactooligosaccharide on constipation

摘要: Objective: Fructooligosacharides and galactooligosacharides soften fecal bolus increase frequency of depositions when added to infant formula. This study aimed determine the effects galactooligosaccharide in pediatric patients with chronic constipation. Methods: From 2010 2012, 20 constipated (4---16 years age) attended at a primary healthcare unit were enrolled double-blinded, placebo-controlled crossover trial. Eleven children ingested (1.7 g) for 30 days, followed by 15day washout period, 30-day period placebo (maltodextrin). Nine maltodextrin 15-day days. Constipation symptoms considered as outcomes: bowel movements/week, straining during defecation, stool consistency. Outcome ranked according numerical scale elaborated this study. Data recorded baseline, on days 15 each period. Repeated-measures analysis variance (ANOVA) was used analyze along time. Results: At there no signi“cant difference severity between groups (p = 0.45). Galactooligosaccharide ingestion related movement frequency, p < 0.0001; relief defecation straining, decrease consistency, 0.0014, compared ingestion. Patients reported side from galactooligosaccharide.