Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia.
作者： Viviane Labrie , Tatiana Lipina , John C. Roder
DOI: 10.1007/S00213-008-1196-6
关键词:
摘要: Rationale Schizophrenic patients demonstrate prominent negative and cognitive symptoms that are poorly responsive to antipsychotic treatment. Abnormal glutamatergic neurotransmission may contribute these pathophysiological dimensions of schizophrenia. Objective We examined the involvement glycine coagonist site on N-methyl-D-aspartate receptor (NMDAR) in modulation endophenotypes mice. Materials methods Behavioral phenotypes relevant schizophrenia were assessed Grin1 D481N mice have
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sci-hub.se 参考文章(63)
Sheryl S. Moy, Antonio Perez, Beverly H. Koller, Gary E. Duncan, Amphetamine-induced disruption of prepulse inhibition in mice with reduced NMDA receptor function. Brain Research. ,vol. 1089, pp. 186- 194 ,(2006) , 10.1016/J.BRAINRES.2006.03.073
Z. Hliňák, I. Krejči, Kynurenic acid and 5,7-dichlorokynurenic acids improve social and object recognition in male rats Psychopharmacology. ,vol. 120, pp. 463- 469 ,(1995) , 10.1007/BF02245819
Yukitaka Morita, Hiroshi Ujike, Yuji Tanaka, Kyohei Otani, Makiko Kishimoto, Akiko Morio, Tatsuya Kotaka, Yuko Okahisa, Masayuki Matsushita, Akiko Morikawa, Kenji Hamase, Kiyoshi Zaitsu, Shigetoshi Kuroda, A Genetic Variant of the Serine Racemase Gene Is Associated with Schizophrenia Biological Psychiatry. ,vol. 61, pp. 1200- 1203 ,(2007) , 10.1016/J.BIOPSYCH.2006.07.025
A Y Goltsov, J G Loseva, T V Andreeva, A P Grigorenko, L I Abramova, V G Kaleda, V A Orlova, Y K Moliaka, E I Rogaev, Polymorphism in the 5′-promoter region of serine racemase gene in schizophrenia Molecular Psychiatry. ,vol. 11, pp. 325- 326 ,(2006) , 10.1038/SJ.MP.4001801
Dave G Mumby, Stephane Gaskin, Melissa J Glenn, Tania E Schramek, Hugo Lehmann, Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts. Learning & Memory. ,vol. 9, pp. 49- 57 ,(2002) , 10.1101/LM.41302
Gary E Duncan, Sheryl S Moy, Antonio Perez, Dawn M Eddy, Wendy M Zinzow, Jeffrey A Lieberman, John N Snouwaert, Beverly H Koller, Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor function. Behavioural Brain Research. ,vol. 153, pp. 507- 519 ,(2004) , 10.1016/J.BBR.2004.01.008
John H. Krystal, Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans Archives of General Psychiatry. ,vol. 51, pp. 199- 214 ,(1994) , 10.1001/ARCHPSYC.1994.03950030035004
Ina Weiner, The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment. Psychopharmacology. ,vol. 169, pp. 257- 297 ,(2003) , 10.1007/S00213-002-1313-X
Paul C Moser, Janice M Hitchcock, Sarah Lister, Paula M Moran, The pharmacology of latent inhibition as an animal model of schizophrenia. Brain Research Reviews. ,vol. 33, pp. 275- 307 ,(2000) , 10.1016/S0165-0173(00)00026-6
C. Rascle, O. Mazas, G. Vaiva, M. Tournant, O. Raybois, M. Goudemand, P. Thomas, Clinical features of latent inhibition in schizophrenia Schizophrenia Research. ,vol. 51, pp. 149- 161 ,(2001) , 10.1016/S0920-9964(00)00162-6