Physiology of the Incretin Hormones, GIP and GLP-1-Regulation of Release and Posttranslational Modifications.
作者： Jens J. Holst , Nicolai J. Wewer Albrechtsen , Mette M. Rosenkilde , Carolyn F. Deacon
DOI: 10.1002/CPHY.C180013
关键词:
摘要: The focus of this article is on the analysis release and postrelease fate incretin hormones, glucagon-like peptide-1 glucose-dependent insulinotropic polypeptide. Their actions are dealt with to extent that they linked their secretion. For both posttranslational processing analyzed in detail, because its importance for understanding molecular heterogeneity hormones. Methods analysis, particular regarding measurements plasma from vivo experiments, discussed detail relation designations "total" versus "intact hormones" explained. Both hormones substrates ubiquitous enzyme, dipeptidyl peptidase-4, which inactivates peptides dramatic consequences physiological spectrum activities. role endogenous exogenous antagonists receptors elucidation physiology pathophysiology Regarding actual secretion, most important factors discussed, including gastric emptying rate influence different macronutrients. Additional bile, paracrine regulation, microbiota, pharmaceuticals, exercise. Finally, secretion during pathological conditions discussed. © 2019 American Physiological Society. Compr Physiol 9:1339-1381, 2019.
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