Bone cancer incidence by morphological subtype: a global assessment.

摘要: To better understand the relevance of environmental factors to changing patterns bone cancer subtypes, we examine incidence osteosarcoma (OS), Ewing sarcoma (ES), and chondrosarcoma (CS) using data from in five continents. Age-specific age-standardized rates (ASRs) per 100,000 person-years were computed stratified by country (n = 43), subtype, sex during 2003–2007. Temporal ASRs examined 1988–2007 (12 countries). Age–period–cohort models fitted for USA UK subtype. For most countries, OS represented 20–40 % all cancers, ES < 20 %, while CS proportions varied more considerably. Overall cancers 0.8–1.2/100,000 men 0.5–1.0 women (0.20–0.35/100,000 0.10–0.30/100,000 both women, <0.10–0.25/100,000 0.05–0.25/100,000 ES). The age-specific revealed a bimodal peak OS, one ES childhood, heterogeneous pattern CS. overall trends are generally flat, but A declining was observed (men), an increase (female), apparent ES, followed leveling off successive US cohorts. Monitoring with assembled geographically broader range registries may generate hypotheses about additional risk ensure that high-risk populations not overlooked control efforts.