T cells with Fc receptors for IgA: induction of T alpha cells in vivo and in vitro by purified IgA.

摘要: Previous studies demonstrated that BALB/c mice with the IgA-secreting plasmacytomas MOPC-315 (alpha lambda 2), MOPC-167 kappa), McPC-603 kappa) and TEPC-15 developed large numbers of T cells surface membrane receptors for IgA (T alpha cells). The lack cell expansion in variant were nonsecretors or low secretors implied elevated serum contributed to increase cells. present show normal given daily injections 30 mg (M315 protein) develop a marked number These also induced by injection are Lyt1-2+ In addition, data presented demonstrate nylon wool nonadherent cells, treated purified polymeric vitro, vitro induction requires DNA protein synthesis. findings indicate observed myeloma is related high level not tumor per se. these observations have more general relevance issue B regulation because they secreted immunoglobulin can directly induce immunoregulatory