T560: a murine lymphoma with receptors for IgA

作者: T D Rao , A A I Maghazachi , J M Phillips-Quagliata

DOI: 10.1007/978-94-009-1848-1_87

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摘要: Tumor 560 is an Ig−, Ia+, B220+ lymphoma that originated in the gut-associated lymphoid tissue (GALT) of a (BI0 X B10.H2a H-4bpWts)F1 hybrid mouse. One line it (T560.1) bears IgA receptors on only low percentage its cells, while second (T560.2), has high receptor-positive cells. These differ, however, from those previously described T cells having affinity not for but also IgM. Thus, some aspects binding activity, T560 receptor resembles poly-Ig which binds to both IgM and transports them across epithelial The is, normally restricted glandular hepatocytes absent Yet another kind present surface contained unseparated Peyer’s patch (PP) cell populations; differs hybridomas being highly inhibitable by IgG3 poorly T560.2 presents antigen antigen-reactive secretes IL-1- IL-6-like activities.

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