Proteoglycans of the Central Nervous System

摘要: The extracellular matrix (ECM) is a complex molecular framework that provides physical support to cells and tissues, while also providing signals for cell growth, migration, differentiation survival. Proteoglycans, as part of the or cell-surface milieu most tissues organ systems, play important roles in morphogenesis by modulating cell-matrix cell-cell interactions, adhesiveness, binding presenting growth factors. basic concept, specialized matrices rich hyaluronan, chondroitin sulfate proteoglycans (CS-PG: aggrecan, versican, neurocan, brevican, phosphacan), link proteins tenascins (Tn-R, Tn-C) can regulate cellular migration axonal thus, actively participate development maturation nervous system, has gained rapidly expanding experimental (Zimmermann Dours-Zimmermann 2008). distribution ECM molecules displays area-specific differences along dorso-ventral axis, delimiting functionally developmentally distinct areas. In gray matter, laminae I II lack PNNs contain low levels glycosaminoglycans (CS-GAGs), tenascin-R, possibly favoring maintenance local neuroplastic properties. Conversely, CS-GAGs, phosphacan were abundant, with numerous thick PNNs, III-VIII X. Motor neurons (lamina IX), surrounded containd various amounts CS-GAGs (Vitellaro-Zuccarello et al. 2007).