Inhibition of GTP-utilizing enzymes by tyrphostins.
作者： P. P. M. Schnetkamp , G. Wolbring , M. D. Hollenberg
DOI: 10.1016/S0021-9258(17)31667-8
关键词:
摘要: Tyrphostins are a group of organic compounds which widely used as tool to specifically inhibit protein tyrosine kinases (Yaish, P., Gazit, A., Gilon, C., and levitzki A. (1988) Science 242, 933-935; Yaish, Levitzki (1989) J. Med. Chem. 32, 2344-2352; Lyall, R. M., Zilberstein, Levitzki, Schlessinger Biol. 264, 14503-14509; Osherov, N., (1993) 268, 11134-11142). We report here that members the tyrphostin family GTPase activity transducin enzymatic activities other GTP-utilizing proteins in retinal rod outer segments, such guanylyl cyclase or fructose-6-phosphate kinase. In contrast, ATP-utilizing enzymes hexokinase rhodopsin kinase were not effected.
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