Dynamics of Transforming Growth Factor Beta Signaling in Wound Healing and Scarring
作者： Kenneth W. Finnson , Sarah McLean , Gianni M. Di Guglielmo , Anie Philip
关键词:
摘要: Significance: Wound healing is an intricate biological process in which the skin, or any other tissue, repairs itself after injury. Normal wound relies on appropriate levels of cytokines and growth factors to ensure that cellular responses are mediated a coordinated manner. Among many studied context healing, transforming factor beta (TGF-β) thought have broadest spectrum effects. Recent Advances: Many molecular mechanisms underlying TGF-β/Smad signaling pathway been elucidated, role TGF-β has well characterized. Targeting using therapeutic agents improve and/or reduce scarring successful pre-clinical studies. Critical Issues: Although isoforms (β1, β2, β3) signal through same cell surface receptors, they display distinct functions during vivo not fully elucidated. The cha...
sci-hub.se 参考文章(171)
Thomas Neill, Liliana Schaefer, Renato V. Iozzo, Decorin: a guardian from the matrix. American Journal of Pathology. ,vol. 181, pp. 380- 387 ,(2012) , 10.1016/J.AJPATH.2012.04.029
G. Cherry, Chen Bi, P. Schmid, D. A. Cox, P. Itin, Enhanced expression of transforming growth factor-beta type I and type II receptors in wound granulation tissue and hypertrophic scar. American Journal of Pathology. ,vol. 152, pp. 485- 493 ,(1998)
R. Wieser, J.L. Wrana, J. Massagué, GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. The EMBO Journal. ,vol. 14, pp. 2199- 2208 ,(1995) , 10.1002/J.1460-2075.1995.TB07214.X
Oliver Eickelberg, Eleonore Köhler, Frank Reichenberger, Sybille Bertschin, Thomas Woodtli, Paul Erne, André P. Perruchoud, Michael Roth, Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-β1 and TGF-β3 American Journal of Physiology-lung Cellular and Molecular Physiology. ,vol. 276, ,(1999) , 10.1152/AJPLUNG.1999.276.5.L814
Nicole Dünker, Kerstin Krieglstein, Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis. FEBS Journal. ,vol. 267, pp. 6982- 6988 ,(2000) , 10.1046/J.1432-1327.2000.01825.X
Keith Brew, Deendayal Dinakarpandian, Hideaki Nagase, Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochimica et Biophysica Acta. ,vol. 1477, pp. 267- 283 ,(2000) , 10.1016/S0167-4838(99)00279-4
Jeffrey L Wrana, Liliana Attisano, Rotraud Wieser, Francesc Ventura, Joan Massagué, None, Mechanism of activation of the TGF-β receptor Nature. ,vol. 370, pp. 341- 347 ,(1994) , 10.1038/370341A0
D B Rifkin, R L Shapiro, I Nunes, Characterization of latent TGF-beta activation by murine peritoneal macrophages. Journal of Immunology. ,vol. 155, pp. 1450- 1459 ,(1995)
Vincent Sarrazy, Fabrice Billet, Ludovic Micallef, Bernard Coulomb, Alexis Desmoulière, Mechanisms of pathological scarring: role of myofibroblasts and current developments. Wound Repair and Regeneration. ,vol. 19, ,(2011) , 10.1111/J.1524-475X.2011.00708.X
JianFei Wang, Jie Ding, Haiyan Jiao, Dariush Honardoust, Moein Momtazi, Heather A. Shankowsky, Edward E. Tredget, Human hypertrophic scar-like nude mouse model: characterization of the molecular and cellular biology of the scar process. Wound Repair and Regeneration. ,vol. 19, pp. 274- 285 ,(2011) , 10.1111/J.1524-475X.2011.00672.X