The role and mechanism of autophagy in sorafenib targeted cancer therapy
作者： Yi Heqing , Long Bin , Ye Xuemei , Li Linfa
DOI: 10.1016/J.CRITREVONC.2016.02.006
关键词:
摘要: Targeting kinase inhibitors (TKIs) are effective tools for treating advanced cancer. However, acquired resistance represents a roadblock in the use of TKIs, such as sorafenib, cancer therapy. Understanding acquisition to sorafenib will help doctors cope with TKIs general and develop personalized medicine strategies patients. Autophagy is biological process that occurs normal organisms. it also component multiple disease processes, including development progression. roles autophagy response therapy controversial. In this review, we summarize progress research, which representative targeted
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