Introduction to DNA Tumor Viruses: Adenovirus, Simian Virus 40, and Polyomavirus

摘要: Human adenovirus, simian virus 40 (SV40), and murine polyomavirus are small DNA viruses, classified as tumor viruses because they can induce tumors in rodents immortalize primary cells vitro. This chapter reviews the historical role of adenovirus SV40 illuminating molecular basis retinoblastoma gene product (pRb) p53 function. More recently recognized interactions between transforming proteins SV40, cell growth control products considered this chapter. papillomaviruses (HPVs) have circular genomes like polyomavirus, but express a series early genes more adenovirus. The contribution E1A large-T-antigen studies to current understanding roles pRb family is discussed Interactions described human adenoviruses, each contributed importantly events that underlie carcinogenesis. Adenovirus with its hosts considerable importance for at least two reasons. One targets major suppressors very effectively, yet, contrast such HPV, has never been associated cancer. second reason interest adenovirus/human biological properties made it an attractive therapy vector. These provided first clear view functional links disparate families cycle-regulating molecules.