Antibodies to recombinant human tissue-transglutaminase in coeliac disease: diagnostic effectiveness and decline pattern after gluten-free diet.
作者： E BAZZIGALUPPI , P ROGGERO , B PARMA , M BRAMBILLASCA , F MERONI
DOI: 10.1016/J.DLD.2005.10.020
关键词:
摘要: Abstract Background/aims To assess the sensitivity and specificity of IgA IgG tissue-transglutaminase antibodies assay, pattern antibody decline after gluten withdrawal their modifications with reference to dietary compliance. Subjects We studied sera from 143 untreated coeliac children adolescents (8.8 ± 6.1 years), 212 97 those patients withdrawal, 64 control subjects non-coeliac intestinal disorders (6.8 ± 4.8 years). Methods Samples were tested for class by radiobinding using human-derived tissue-transglutaminase, anti-endomysium indirect immunofluorescence on monkey oesophagus. Results Untreated had significantly higher titres than controls (p Conclusions The recombinant human assay is a highly sensitive specific test diagnosis disease, it useful in monitoring compliance gluten-free diet.
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sci-hub.se 参考文章(34)
Michael N. Marsh, Gluten, major histocompatibility complex, and the small intestine: A molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’) Gastroenterology. ,vol. 102, pp. 330- 354 ,(1992) , 10.1016/0016-5085(92)91819-P
Kouroche Vahedi, Francoise Mascart, Jean-Yves Mary, Jean-Eric Laberenne, Yoram Bouhnik, Marie-Christine Morin, Annick Ocmant, Christine Velly, Jean-Frederic Colombel, Claude Matuchansky, Reliability of antitransglutaminase antibodies as predictors of gluten-free diet compliance in adult celiac disease. The American Journal of Gastroenterology. ,vol. 98, pp. 1079- 1087 ,(2003) , 10.1111/J.1572-0241.2003.07284.X
J. Seissler, S. Boms, U. Wohlrab, N. Morgenthaler, T. Mothes, B. Boehm, W. Scherbaum, Antibodies to human recombinant tissue transglutaminase measured by radioligand assay: evidence for high diagnostic sensitivity for celiac disease. Hormone and Metabolic Research. ,vol. 31, pp. 375- 379 ,(1999) , 10.1055/S-2007-978758
Mona Amin, Thomas Eckhardt, Susanne Kapitza, Burkhard Fleckenstein, Günther Jung, Jochen Seissler, Henry Weichert, Thomas Richter, Martin Stern, Thomas Mothes, Correlation between tissue transglutaminase antibodies and endomysium antibodies as diagnostic markers of coeliac disease. Clinica Chimica Acta. ,vol. 282, pp. 219- 225 ,(1999) , 10.1016/S0009-8981(99)00009-1
A.J.K Williams, P Annis, R.J Lock, D.J Unsworth, E.A.M Gale, P.J Bingley, Evaluation of a high-throughput second antibody radiobinding assay for measuring IgA antibodies to human tissue transglutaminase. Journal of Immunological Methods. ,vol. 228, pp. 81- 85 ,(1999) , 10.1016/S0022-1759(99)00099-X
A. Lenhardt, A. Plebani, F. Marchetti, T. Gerarduzzi, T. Not, A. Meini, V. Villanacci, S. Martelossi, A. Ventura, Role of human-tissue transglutaminase IgG and anti-gliadin IgG antibodies in the diagnosis of coeliac disease in patients with selective immunoglobulin A deficiency. Digestive and Liver Disease. ,vol. 36, pp. 730- 734 ,(2004) , 10.1016/J.DLD.2004.06.017
Edward J. Hoffenberg, Fei Bao, George S. Eisenbarth, Cynthia Uhlhorn, Joel E. Haas, Ronald J. Sokol, Marian Rewers, Transglutaminase antibodies in children with a genetic risk for celiac disease The Journal of Pediatrics. ,vol. 137, pp. 356- 360 ,(2000) , 10.1067/MPD.2000.107582
LOCK, GILMOUR, UNSWORTH, Anti-tissue transglutaminase, anti-endomysium and anti-R1-reticulin autoantibodies-the antibody trinity of coeliac disease. Clinical and Experimental Immunology. ,vol. 116, pp. 258- 262 ,(1999) , 10.1046/J.1365-2249.1999.00909.X
M Mayer, L Greco, R Troncone, S Auricchio, M N Marsh, Compliance of adolescents with coeliac disease with a gluten free diet. Gut. ,vol. 32, pp. 881- 885 ,(1991) , 10.1136/GUT.32.8.881
Tony Hansson, Ingrid Dahlbom, Jeanette Hall, Anette Holtz, Lena Elfman, Anders Dannaeus, Lars Klareskog, Antibody reactivity against human and guinea pig tissue transglutaminase in children with celiac disease Journal of Pediatric Gastroenterology and Nutrition. ,vol. 30, pp. 379- 384 ,(2000) , 10.1097/00005176-200004000-00006